Mood Disorders Research Program

Hilary P. Blumberg
The John and Hope Furth Professor of Psychiatric Neuroscience, and Professor of Diagnostic Radiology and in the Child Study Center
Director, Mood Disorders Research Program

Mood Disorders Research Program

Mission:

The Yale Mood Disorders Research Program (MDRP) is dedicated to understanding the science of mood disorders, including bipolar disorder (manic-depressive illness) and depression. The MDRP brings together a multi-disciplinary group of scientists from across the Yale campus in a highly collaborative research effort. We use a wide variety of scientific methods to study how genetic and environmental factors affect the brain and lead to the development of mood disorders. Goals of the MDRP include the identification of biological markers for mood disorders and discovery of new treatment strategies. We hope that these research efforts will lead to new and improved methods for early detection and treatment, and someday prevention, of mood disorders.

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Research Portfolio:

  • State-of-the-Art Brain Scanning (including MRI, fMRI, DTI) 
  • Genetics
  • Behavior and Cognition
  • Disorders in Adolescents and Adults: Bipolar Disorder, Major Depressive Disorder
  • Treatment
  • Stress
  • Suicide Prevention
  • Women and Mood Disorders

Who is eligible to participate in research?

  • Adolescents with Bipolar Disorder
  • Adults with Bipolar Disorder
  • Family members of individuals with Bipolar Disorder
  • Adolescents with depression
  • Healthy adolescents and adults to study healthy brain development
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News About Us:

Contact Us:

For more information about MDRP research programs, or if you would like to participate in one of the studies, please call Susan Quatrano at 203-785-7875.

Selected Publications:

  • Johnston, J.A.Y, F. Wang, J. Liu, B. Blond, A. Wallace, J. Liu, L. Spencer, E.T. C. Lippard, Purves, K.L., A. Landeros-Weisenberger, E. Hermes, B. Pittman, R. King, A. Martin, M. Oquendo, H.P. Blumberg. American Journal of Psychiatry, 2017, Jan 31:appiajp 201615050652. doi:10.1176/appi.ajp. 2016.15050652. [Epub ahead of print]. Multimodal imaging of fronto-limbic structure and function associated with suicide attempts in adolescents and young adults with bipolar disorder. American Journal of Psychiatry.
  • Lippard, E.T.C., K.P. Jensen, F. Wang, J.A.Y. Johnston, L. Spencer, B. Pittman, J. Gelernter, H.P. Blumberg. Molecular Psychiatry, 2016 May 31. doi: 10.1038/mp.2016.76. [Epub ahead of print]. Effects of ANK3 variation on gray and white matter in bipolar disorder. Molecular Psychiatry.
  • Najt, P., F. Wang, L. Spencer, J.A.Y. Johnston, E.T. Cox Lippard, B.P. Pittman, C. Lacadie, L.H. Staib, X. Papademetris, H.P. Blumberg. Biological Psychiatry. 2016, 79:303-310. Anterior cortical development during adolescence in bipolar disorder. Biological Psychiatry.
  • Edmiston, E.E., F. Wang, C.M. Mazure, J. Guiney, R. Sinha, L.C. Mayes, H.P. Blumberg. Archives of Pediatrics and Adolescent Medicine. 2011, 165:1069-1077. Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment. Archives of Pediatrics and Adolescent Medicine.
  • Wang, F., J.H. Kalmar, F.Y. Womer, E.E. Edmiston, L.G. Chepenik, B. R. Chen, L. Spencer, H.P. Blumberg. Brain. 2011, 134:2005-2012. Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder. Brain.
  • Wang, F., J.H. Kalmar, Y. He, M. Jackowski, L.G. Chepenik, E.E. Edmiston, K. Tie, G. Gong, M.P. Shah, M. Jones, J. Uderman, R.T. Constable, H.P. Blumberg. Biological Psychiatry. 2009, 66:516-521. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biological Psychiatry.
  • Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study Blumberg, H.P., J.H. Krystal, R. Bansal, A. Martin, J. Dziura, K. Durkin, L. Martin, E. Gerard, D.S. Charney, B.S. Peterson. Biological Psychiatry. 2006, 59:611-618.
  • Blumberg HP, Kaufman J, Martin A, Whiteman R, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampus volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry 2003;60:1201-1208 Archives of General Psychiatry 2003, 60:601-609.
  • Blumberg HP, Leung HC, Skudlarski P, Lacadie C, Fredericks C, Harris B, Charney D, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry 2003;60: 599-607. Archives of General Psychiatry 2006, 59:611-618.
  • Rostral and orbital prefrontal dysfunction in the manic state of bipolar disorder Blumberg, H.P., E. Stern, S. Ricketts, D. Martinez, J. de Asis, T. White, J. Epstein, N. Isenberg, P.A. McBride, I. Kemperman, S. Emmerich, V. Dhawan, D. Eidelberg, J.H. Kocsis, D.A. Silbersweig. American Journal of Psychiatry. 1999, 156:1986-1988.

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