Kelly P Cosgrove PhD Clin

Associate Professor of Psychiatry, of Diagnostic Radiology and of Neurobiology

Research Interests

Single Photon Emission Computed Tomography; Positron Emission Tomography; Neuroimaging; Alcohol Dependence; Tobacco Smoking; Nicotine Dependence; Brain; nicotinic acetylcholine receptor; GABAA-benzodiazepine receptor; Sex differences

Current Projects

  • Understanding the genetic basis of the changes in beta2*-nicotinic acetylcholine receptor availability during acute and prolonged abstinence in tobacco smokers.
  • Examining the changes in GABAA-benzodiazepine receptor availability that occur during acute and prolonged abstinence from alcohol and nicotine dependence.
  • Radiotracer development targeted at the estrogen receptor and the peripheral benzodiazepine receptor.
  • Examination of nicotine-induced dopamine release using PET brain imaging.
  • Understanding the role sex and hormonal status plays in brain changes in tobacco smokers.
  • Test-Retest Reproducibility of {11C} PHNO PET using the Constant Infusion Paradigm.

Research Summary

Our laboratory is interested in examining the neurochemical and molecular basis of addiction and psychiatric disorders using single photon emission computed tomography (SPECT) and positron emission tomography (PET) brain imaging. We have been interested in the modulation of the beta2-nicotinic acetylcholine receptor during acute and prolonged abstinence in tobacco smokers. We are beginning to uncover the variables, such as sex, psychiatric status and genetic makeup that influence these changes between individuals and groups. Additionally we are examining the cognitive changes that occur upon smoking cessation and we have begun to delineate the effects of various nicotine replacement strategies on cognition and the relationship with receptor occupancy.

Extensive Research Description

We are also examining the interaction of tobacco smoking, nicotine, and alcohol at the GABAA-benzodiazepine receptor over the course of alcohol withdrawal in clinical populations and with a preclinical model. We are interested specifically in how nicotine and tobacco smoke modulate the alcohol-induced changes in GABAA-benzodiazepine receptor availability, which is critically tied to the alcohol withdrawal syndrome. In addition we are interested in the relationship between receptor availability and behavioral characteristics, such as executive function, severity of withdrawal, and alcohol history.

Selected Publications

  • Cosgrove, K.P., Batis, J., Bois, F., Esterlis, I., Kloczynski, T., Stiklus, S., Maciejewski, P.K., Krishnan-Sarin, S., O’Malley, S., Perry, E., Tamagnan, G., Seibyl, J., and Staley, J.K. (2009) ß2-nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Archives of General Psychiatry, 66, 666-676.
  • Cosgrove, K.P., Krantzler, E., Perry, E., Frohlich, E., Stiklus, S., Pittman, B., Tamagnan, G., Baldwin, R., Bois, F., Seibyl, J.P., Krystal, J.H., and Staley, J.K. (2009) [123I]beta-CIT imaging of dopamine and serotonin transporter availability in heavy alcohol drinkers during acute withdrawal. Neuropsychopharmacology, 34, 2218-2226.
  • Cosgrove, K.P., Mazure, C.M., and Staley, J.K. (2007). Evolving knowledge of sex differences in brain structure, function and chemistry. Biological Psychiatry, 62, 847-855.
  • Cosgrove, K.P., Mitsis, E.M., Bois, F., Frohlich, E., Krantzler, E., Epperson, C.N., Perry, E., Tamagnan, G., Seibyl, J.P., Allen, S., O’Malley, S., Mazure, C.M., van Dyck, C., and Staley, J.K. (2007) [123I]5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual cycle phase. J. Nuc. Med., 48, 1633-1640.
  • Staley, J.K., Krishnan-Sarin, S., Cosgrove, K.P., Krantzler, E., Frohlich, E., Perry, E., Dubin, J., Brenner, E., Baldwin, R.M., Tamagnan, G., Seibyl, J.P., Picciotto, M.R., London, E.D., O’Malley, S. and van Dyck, C.H. (2006). ß2*nicotinic acetylcholine receptor availability in recently abstinent smokers. J. Neuroscience, 26, 8707-8714.
  • Esterlis, I., Cosgrove, K.P., Batis, J.C., Bois, F., Kloczynski T.A., Stiklus S.M., Perry, E.B., Tamagnan, G.D., Seibyl, J.P., Makuch, R., Krishnan-Sarin, S, O’Malley, S., and Staley, J.K. (2009) GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression. Synapse, 63, 1089-1099.

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