Godfrey D Pearlson MA, MD, MBBS
Professor of Psychiatry and of Neurobiology
Endophenenotypes; multivariate genotype/phenotype relationships; psychosis; addiction; fMRI, DTI
BSNIP:Bipolar Schizophrenia Network on Intermediate Phenotypes. A 3000-person study examining multiple endophenotypes in individuals with schizophrenia, psychotic bipolar disorder and schizoaffective disorder and their first-degree relatives that includes functional and structural imaging, EEG, cognitive and oculomotor testing and genotyping.
PARDIP:Psychosis and Related Domains- Intermediate Phenotypes. Similar to BSNIP, but conducted in non-psychotic bipolar patients and controls
BARCS:Brain and Alcohol Research in College Students. A longitudinal study that examines 2100 local college students for alcoholism risk using genotyping and multiple endophenotypes including EEG and structural/functional imaging over a 24-month period. This study includes regular Web-based reporting.
Large-scale studies of individuals with major psychiatric disorders and their close relatives, and of healthy persons, combining genotyping results with biological measurements to determine risk of both neuropsychiatric disorders, and associations of normal behaviors and personality traits.
Extensive Research Description
Large-scale, multi-disciplinary, multi-center, endophenotype-genotype investigations to study genetic determinants of pathologic conditions, including psychosis & alcoholism, as well as quantitative traits such as impulsivity and affective instability. Many of the data from these investigations are analyzed using multivariate statistical techniques such as parallel independent component analysis.