[123I]5-IA-85380 SPECT Imaging of β2-containing Nicotinic Acetylcholine Receptors in Depressed Subjects

Trial Purpose and Description

Trial Purpose

This study is looking to determine if depressed nonsmokers and smokers have abnormal regional expression of neuronal β₂-containing nicotinic acetylcholine receptor compared to euthymic control patients

Participation Guidelines

Eligibility Criteria

Inclusion Criteria:

• Diagnosis of bipolar disorder
• No medications

Exclusion Criteria:

• Substance abuse (except caffeine) within the preceding 12 months
• Pregnancy/nursing
• Any MRI contraindications
• Prior radiation exposure within the past year such that participation in this study would place them over FDA limits for annual radiation exposure

Sponsor:

National Institute of Mental Health (NIMH)

Dates:

7/16/2009 - 5/31/2012

Last Updated:

Study HIC#:

0301023934

Clinicaltrials.gov ID: Yale79460871