[123I]5-IA-85380 SPECT Imaging of β2-containing Nicotinic Acetylcholine Receptors in Depressed Subjects

Conditions

Bipolar Disorder

Trial Phase

Trial Purpose and Description

Trial Purpose

This study is looking to determine if depressed nonsmokers and smokers have abnormal regional expression of neuronal β2-containing nicotinic acetylcholine receptor compared to euthymic control patients


Participation Guidelines

Age:
18 Years - 65 Years
Gender:
Both

Eligibility Criteria

Inclusion Criteria:

  • Diagnosis of bipolar disorder
  • No medications

Exclusion Criteria:

  • Substance abuse (except caffeine) within the preceding 12 months
  • Pregnancy/nursing
  • Any MRI contraindications
  • Prior radiation exposure within the past year such that participation in this study would place them over FDA limits for annual radiation exposure
Sponsor:
National Institute of Mental Health (NIMH)
Dates:
7/16/2009 - 5/31/2012
Last Updated:
Study HIC#:
0301023934