The Effect of Interferon-alpha Treatment on Microglia and Glutamate Receptors

Conditions

Major Depressive Disorder

Trial Phase

Trial Purpose and Description

Trial Purpose

This study attempts to measure the microglial activation and metabotropic glutamate receptor type 5 (mGluR5) availability in depressed subjects


Participation Guidelines

Age:
18 Years - 65 Years
Gender:
Both

Eligibility Criteria

Inclusion Criteria:

  • Diagnosis of major depressive disorder (MDD)
  • Currently depressed
  • No medications

Exclusion Criteria:

  • Substance abuse (except caffeine and nicotine) within the preceding 6 months
  • Pregnancy/nursing
  • Any MRI contraindications
  • Prior radiation exposure with the past year such that participation in this study would place them over FDA limits for annual radiation exposure
  • BMI greater than 30
Sponsor:
Society for Nuclear Medicine (SNM)
 
The Nancy Taylor Foundation for Chronic Diseases, Inc.
Dates:
7/1/2010 - 6/30/2012
Last Updated:
Study HIC#:
1008007260