The Effect of Antidepressants on Endotoxin-induced Depressive Symptoms

Conditions

Healthy Subjects

Trial Phase

Trial Purpose and Description

Trial Purpose

There are two main objectives to this study:

1. To determine whether depressive symptoms occur with low-dose endotoxin administration

2. To determine whether pre-treatment with the antidepressant Wellbutrin will lessen endotoxin-induced depressive symptoms


Participation Guidelines

Age:
18 Years - 50 Years
Gender:
Both

Eligibility Criteria

Inclusion Criteria:

  • 18 - 50 years old
  • Medically healthy subjects ;
  • No ;psychiatric history
  • No ;medications
  • No ;drugs or excessive alcohol use

;

Exclusion Criteria:

  • Substance abuse (except caffeine and tobacco) within the preceding 6 months
  • History of psychiatric disorders
  • Pregnancy/breast feeding
  • Presence of acute or unstable medical or neurological illness
  • BMI>;30
  • History of vasovagal symcope or seizures
Sponsor:
National Alliance for Research on Schizophrenia and Depression
Dates:
1/1/2010 - 12/31/2011
Last Updated:
Study HIC#:
0801003419