Yale Depression Research Program

Principal Investigator

Gerard Sanacora, MD, PhD


The Yale Depression Research Program is committed to advancing the treatment of unipolar depression by improving our ability to diagnose and treat mood disorders through a variety of research studies.

Who is eligible for research?

For most studies, men and women between 18 and 65 years of age who meet criteria for major depression and are free from recent drug and/or alcohol abuse are potentially eligible.

Evaluation Process

Potential subjects will be screened by phone to rule out any obvious exclusion criteria.  Those who may be eligible for a study will be invited to our clinic for a comprehensive evaluation free of charge.

Contact Us

For more information about our clinic and current research studies, please call Donna Fasula at 203-764-9131.

Web Site

Visit the Yale Depression Research Program's web site. >>

Current Studies

Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)
Disease/Condition: Treatment Resistant Depression
Principal Investigator: Gerard Sanacora
Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
Disease/Condition: Depression
Principal Investigator: Chadi Abdallah
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 13C-MRS
Disease/Condition: Cocaine Dependence
Principal Investigator: Robert Malison
PET imaging of mGluR5 with drug challenge
Disease/Condition: Major Depressive Disorder
Principal Investigator: Irina Esterlis
Structural and Spectroscopy Pharmaco-Imaging Paradigm to Investigate the Effect of Riluzole in Patients with Post-Traumatic Stress Disorder (PTSD)
Disease/Condition: PTSD
Principal Investigator: Chadi Abdallah