Alan Anticevic PhD
Associate Research Scientist in Psychiatry; Administrative Director, NIAAA Center for the Translational Neuroscience of Alcoholism
schizophrenia, psychotic disorders, working memory, emotion regulation, substance abuse, functional neuroimaging methods, functional connectivity
Area 1: Pharmacological Neuroimaging & Computational Modeling
Area 2: Cognition-Emotion Interactions in Psychiatric Illness
Area 3: Functional Connectivity & Individual Differences in Psychiatric Illness
Extensive Research Description
Broadly, our group is interested in cognitive neuroscience of psychiatric illness. We seek to better understand, at the neural system level, the neural mechanisms behind cognitive and affective deficits in neuropsychiatric illness. Specifically, the research in our group focuses on understanding these processes in schizophrenia, bipolar illness and addiction. We use a combination of tools to better understand the neural systems involved in processing affective stimuli and their interaction with neural systems involved in goal-directed cognitive operations such as working memory. Methodologically, our lab harnesses the combination of task-based, resting-state, pharmacological functional neuroimaging, as well as computational modeling approaches to mechanistically understand neural circuit dysfunction in psychiatric disorders. Our experimental approaches depend on the combination of these tools to better understand the mechanistic links between neural circuit dysfunction and complex cognitive and affective processes and behaviors. The overarching objective of the lab is better understand the underlying neural circuit dysfunction in complex mental illness such as schizophrenia, with the aim of developing better neural markers and informing rationally-guided pharmacological treatments.
- Anticevic, A., Cole, M.W., Murray, J.D., Corlett, P.R., Wang, X-J., Krystal, J.H. (2012) The role of default network deactivation in cognition and disease. Trends in Cognitive Sciences. 16(12):584-92
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D''Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT and Krystal JH: Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Mol Psychiatry. 2013 Jan 22 Epub 2013 Jan 22. PMID: 23337947
- Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N.R., Ennis, D.J., Niciu, M.J., Morgan, P.T., Surti, T., Smith, M., Wang, X-J., Krystal*, J.H., & Corlett*, P.R. (2012). NMDA receptor antagonism disrupts anti-correlated neural systems with implications for cognition and schizophrenia. *denotes equal contribution. Proceedings of the National Academy of Sciences. 109(41):16720-5.
- Anticevic, A., Brumbaugh, M.S., Winkler, A.M., Lombardo, L.E., Barrett, J., Corlett, P.R., Kober, H., Gruber, J., Repovs, G., Cole, M.W., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2012). Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biological Psychiatry. doi: 10.1016/j.biopsych.2012.07.031
- Anticevic, A., & Corlett, P.R. (2012). Cognition-emotion dysinteraction in schizophrenia. Frontiers Research Topic: The Impact of Emotion on Cognition – Dissociating between Enhancing and Impairing Effects. Frontiers in Psychology.
- Anticevic, A., Repovs, G., Krystal, J.H., & Barch, D.M. (2012). A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research. 141(1):8-14
- Anticevic, A., Krystal, J.H., & Barch, D.M. (2012). Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches towards understanding cognitive deficits. In “Cognitive impairment in schizophrenia: characteristics, assessment, and treatment”. Ed. Phil Harvey. Cambridge University Press. (Email for Reprint).
- Cole, M.W. , Yarkoni, T., Repovs, G., Anticevic, A., & Braver, T.M. (2012). Global connectivity of prefrontal cortex predicts cognitive control and intelligence. Journal of Neuroscience. 32(26):8988-8999.
- Anticevic, A., Van Snellenberg, J.X., Barch, D.M. (2012). Neurobiology of Emotional Dysfunction in Schizophrenia: New Directions Revealed Through Meta-analyses. Biological Psychiatry. 71(6):e23-4.
- Anticevic, A., Repovs, G., Dierker, D., Harwell, J., Coalson, T., Barch, D.M., & Van Essen, D.C. (2011). Evaluation of Automated Landmark Identification for Human Cortical Surface-Based Registration. NeuroImage. 59(3):2539-47.