Affect; Cognition; Emotions; Memory, Short-Term; Schizophrenia; Substance-Related Disorders
Psychiatry: Anticevic Lab | Center for the Translational Neuroscience of Alcoholism | Clinical Neuroscience Research Unit | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Psychology Section
Extensive Research Description
Broadly, our group is interested in cognitive neuroscience of psychiatric illness. We seek to better understand, at the neural system level, the neural mechanisms behind cognitive and affective deficits in neuropsychiatric illness. Specifically, the research in our group focuses on understanding these processes in schizophrenia, bipolar illness and addiction. We use a combination of tools to better understand the neural systems involved in processing affective stimuli and their interaction with neural systems involved in goal-directed cognitive operations such as working memory. Methodologically, our lab harnesses the combination of task-based, resting-state, pharmacological functional neuroimaging, as well as computational modeling approaches to mechanistically understand neural circuit dysfunction in psychiatric disorders. Our experimental approaches depend on the combination of these tools to better understand the mechanistic links between neural circuit dysfunction and complex cognitive and affective processes and behaviors. The overarching objective of the lab is better understand the underlying neural circuit dysfunction in complex mental illness such as schizophrenia, with the aim of developing better neural markers and informing rationally-guided pharmacological treatments.
- Anticevic, A.*, Murray, J.D.*, Barch, D.M. (2015). Bridging Levels of Understanding in Schizophrenia Through Computational Modeling. Clin Psychol Sci., 3(3):433-459. * Denotes shared 1st authorship.
- Yang, J.G., Murray, J.D., Repovs, G., Cole, M.W., Savic, A., Glasser, M., Pittenger, C., Krystal, J.H., Wang, X-J. Pearlson, D.G., Glahn, D.C., Anticevic, A. (2014). Altered global signal in schizophrenia. Proceedings of the National Academy of Sciences.
- Anticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M.W., Bednarski, S., Krystal, J.H., Bloch, M.B., Li, R.C-S., Pittenger, C. (2014). Global resting-state fMRI analysis identifies frontal cortex, striatal, and ce
- Cole, M.W., Repovs, G., & Anticevic, A. (2014). The fronto-parietal control system: A central role in mental health. Neuroscientist. 20(6):652-64.
- Anticevic, A., Savic, A., Repovs, G., Yang, G., McKay, D.R, Sprooten, E., Knowles, E., Krystal, J.H. Pearlson, G.D., Glahn, D.C. Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2014). Ventral anterior cingulate connectivity distinguished non-psychotic bipol
- Anticevic, A.*, Tang, Y.*, Cho, Y.T., Repovs, G., Cole, M.W., Savic, A., Wang, F., Krystal, J.H., & Xu, K. (2014) Amygdala connectivity at rest distinguishes between chronic, 1st episode and individuals at high risk for developing schizophrenia. *Denotes
- Anticevic, A., Cole, M.W., Repovs, G., Savic, A., Driesen, N.R., Yang, G., Cho, Y.T., Murray, J.D., Glahn, D.C., Wang, X-J. and Krystal, J.H. (2013) Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfuncti
- Anticevic, A., Cole, M.W., Repovs, G., Murray J.D., Brumbaugh, M.S., Winkler, A.M., Savic, A., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2014). Thalamo-cortical disturbances in schizophrenia and bipolar illness. Cerebral Cortex. 24(12):3116-30.
- Cole, M.W., Reynolds, J.R., Bassett, D., Power, J.D., Repovs, G., Anticevic, A., Braver, T.S. (2013). Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience. 16(9):1348-55.
- Anticevic, A., Cole, M.W., Murray, J.D., Corlett, P.R., Wang, X-J., Krystal, J.H. (2012) The role of default network deactivation in cognition and disease. Trends in Cognitive Sciences. 16(12):584-92
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT and Krystal JH: Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMD
- Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N.R., Ennis, D.J., Niciu, M.J., Morgan, P.T., Surti, T., Smith, M., Wang, X-J., Krystal*, J.H., & Corlett*, P.R. (2012). NMDA receptor antagonism disrupts anti-correlated neural systems with
- Anticevic, A., Brumbaugh, M.S., Winkler, A.M., Lombardo, L.E., Barrett, J., Corlett, P.R., Kober, H., Gruber, J., Repovs, G., Cole, M.W., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2012). Global prefrontal and fronto-amygdala dysconnectivity in bipolar
- Anticevic, A., & Corlett, P.R. (2012). Cognition-emotion dysinteraction in schizophrenia. Frontiers Research Topic: The Impact of Emotion on Cognition – Dissociating between Enhancing and Impairing Effects. Frontiers in Psychology.
- Anticevic, A., Repovs, G., Krystal, J.H., & Barch, D.M. (2012). A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research. 141(1):8-14
- Anticevic, A., Krystal, J.H., & Barch, D.M. (2012). Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches towards understanding cognitive deficits. In “Cognitive impairment in schizophrenia: characteri
- Cole, M.W. , Yarkoni, T., Repovs, G., Anticevic, A., & Braver, T.M. (2012). Global connectivity of prefrontal cortex predicts cognitive control and intelligence. Journal of Neuroscience. 32(26):8988-8999.
- Anticevic, A., Van Snellenberg, J.X., Barch, D.M. (2012). Neurobiology of Emotional Dysfunction in Schizophrenia: New Directions Revealed Through Meta-analyses. Biological Psychiatry. 71(6):e23-4.
- Anticevic, A., Repovs, G., Dierker, D., Harwell, J., Coalson, T., Barch, D.M., & Van Essen, D.C. (2011). Evaluation of Automated Landmark Identification for Human Cortical Surface-Based Registration. NeuroImage. 59(3):2539-47.
- Anticevic, A., Repovs, G., & Barch, D.M. (2011). Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities. Schizophrenia Bulletin.
- Anticevic, A., Repovs, G., Corlett, P.R., & Barch, D.M. (2011). Negative and Non-emotional Interference with Visual Working Memory in Schizophrenia. Biological Psychiatry. 70(12):1159-68.
- Cole, M.W., Anticevic, A., Repovs, G., & Barch, D.M. (2011). Variable global dysconnectivity and individual differences in schizophrenia. Biological Psychiatry. 70(1), 43-50.
- Anticevic, A., Repovs, G., & Barch, D.M. (2011). Emotion Effects on Attention, Amygdala Activation and Functional Connectivity in Schizophrenia. Schizophrenia Bulletin.
- Anticevic, A.*, Van Snellenberg, J.X.*, Repovs, G., & Barch, D.M. (2010). Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies. Schizophrenia Bulletin. * Shared 1st authorship.
- Anticevic, A., Repovs, G., & Barch, D.M. (2010). Resisting emotional interference: brain regions facilitating working memory performance during emotional distraction. Cognitive, Affective & Behavioral Neuroscience. 10(2), 159-173.
- Anticevic, A., Repovs, G., Shulman, G.L., & Barch, D.M. (2010). When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage, 49(3), 2638-48.
- Anticevic, A., Dierker, D., Gillespie, S.K., Repovs, G., Van Essen, D.C., Csernansky, J.G., & Barch, D.M. (2008). Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia. Neuroimage, 41(3), 835-48.